The confused cancer patient: a case of 5-fluorouracil–induced encephalopathy
نویسندگان
چکیده
The fluorinated pyrimidine 5-fluorouracil (5-FU) is an anticancer agent used in most adjuvant and palliative treatment regimens for colorectal cancer. Neurotoxicities are considered extremely rare side effects of 5-FU. Here, we report a case of 5-FU-induced encephalopathy, manifesting as seizures and delirium, in an era of oxaliplatin-containing chemotherapy. If ammonia levels are elevated, lactulose may be considered in the initial management of neuropsychiatric complications from 5-FU.
منابع مشابه
Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy.
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following ...
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A case of hyperammonaemic encephalopathy that developed during the administration of a widely used chemotherapy regimen is reported in a 51-year-old man. 5-Fluorouracil was considered to be the causative agent. Although encephalopathy is a rare toxic effect of 5-fluorouracil, this case illustrates a serious and potentially life-threatening complication during a chemotherapy regimen using 5-fluo...
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عنوان ژورنال:
- Current Oncology
دوره 15 شماره
صفحات -
تاریخ انتشار 2008